Titlebook: Stem Cell Biology in Neoplasms of the Central Nervous System; Moneeb Ehtesham Book 2015 The Editor(s) (if applicable) and The Author(s), u

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Radiation Therapy for Glioma Stem Cells,survival has been recognized for decades. Cancer stem cells provide new insights into how tumor biology is affected by radiation and the role that this cell population can play in disease recurrence. Glioma stem cells possess a variety of intracellular mechanisms to resist and even flourish in spite

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Chemoresistance and Chemotherapy Targeting Stem-Like Cells in Malignant Glioma,ve chemotherapy and give rise to tumor recurrences that invariably result in the death of the patients. Here we summarize the current knowledge on chemoresistance of malignant glioma with a strong focus on GSC. Chemoresistant GSC are the most likely cause of tumor recurrence, but it remains controve

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Arteriography

Chemoresistance and Chemotherapy Targeting Stem-Like Cells in Malignant Glioma,ion is regulated by extrinsic factors like hypoxia increasing MGMT expression and thereby resistance to alkylating chemotherapy. The search of new biomarkers helping to predict the tumor response to chemotherapy is ongoing and will complement the already known markers like MGMT.

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Immunobiology and Immunotherapeutic Targeting of Glioma Stem Cells,currence. Here we review research progress in immunotherapy as it pertains to glioma treatment and how it can and is being adapted to target glioma stem cells (GSCs) as a means of dealing with this potential paradigm.

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0065-2598 s disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control. .978-3-319-34851-3978-3-319-16537-0Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Vivian Capilla-Gonzalez,Emily Lavell,Alfredo Quiñones-Hinojosa,Hugo Guerrero-Cazares M.D., Ph.D.bolic activity are mentioned in the third part of this chapter as examples of novel enzymes identified through traditional purification from cells. Also discussed is detection of unexpected activities of gene products not predicted from the genomic data through activity analysis.