Titlebook: Stem Cell Biology in Neoplasms of the Central Nervous System; Moneeb Ehtesham Book 2015 The Editor(s) (if applicable) and The Author(s), u

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Radiation Therapy for Glioma Stem Cells,is for our current use of radiation to treat high-grade gliomas, and addresses this model in the context of therapeutically resistant stem cells. We discuss the available evidence highlighting current clinical efforts to improve radiosensitivity, and newer targets worthy of further development.

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AWL

Isolation and Characterization of Stem Cells from Human Central Nervous System Malignancies,lls in detail and to accomplish this, we need to be able to reliably isolate and characterize these cells. This chapter will therefore, provide an overview of the methods used to isolate and characterize stem cells from human CNS malignancies.

INERT

The Role of Stem Cells in Pediatric Central Nervous System Malignancies,nable future clinical approaches to harness the heterogeneous cellular and genomic landscape of these solid tumors as an avenue for developing targeted patient-oriented therapies, thereby improving the overall survivorship for the most lethal childhood cancer.

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Laboratory Models for Central Nervous System Tumor Stem Cell Research,es. This understanding will help identify and develop more effective and comprehensive treatment strategies. This chapter provides an overview of some of the most commonly used laboratory models for CNSTSC research.

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Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain,d neuroblasts from the SVZ form cellular chains that migrate through the rostral migratory stream (RMS) into the olfactory bulb (OB), where they become mature neurons. Migration through the RMS is a highly regulated process of intrinsic and extrinsic factors, orchestrated to achieve direction and in

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The SVZ and Its Relationship to Stem Cell Based Neuro-oncogenesis,brain containing neuronal stem and progenitor cell populations has led to the hypothesis that these cells may themselves serve as an origin of brain tumors. Stem cells that reside within the glioma tumor have been shown to display nonneoplastic stem-like characteristics, including expression of vari

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NAG

The Role of Stem Cells in Pediatric Central Nervous System Malignancies,ions, cellular populations, treatment protocols, and clinical outcomes. In this chapter we discuss recent and emerging data that implicate cancer stem cells (also known as brain tumor-initiating cells) in initiating and maintaining the growth of a number of pediatric brain tumors including: medullob

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