Titlebook: Statistics Applied to Clinical Trials; Ton J. Cleophas,Aeilko H. Zwinderman,Toine F. Cleo Book 20063rd edition Springer Science+Business M

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Crossover Studies with Continuous Variables: Power Analysis,ontrolled hypertension trials in 1993 were accordingly designed.. A major advantage of the crossover design is that it eliminates between-subject variability of symptoms. However, problems include the occurrence of carryover effect, sometimes wrongly called treatment-by-period interaction (see also

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Controlling the Risk of False Positive Clinical Trials,testing, which increases the risk of false positive results, otherwise called type I errors. There is no consensus within the statistical community on how to cope with this problem. Also, the issue has not been studied thoroughly for every type of variable. Clinical trials rarely adjust their data f

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Principles of Linear Regression,rch things are essentially different: data are obtained from the observation of populations or the retrospective observation of patients selected because of a particular condition or illness. Conclusions are limited to the establishment of relationships, causal or not. We currently believe that rela

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