Titlebook: Statistics Applied to Clinical Trials; Ton J. Cleophas,Aeilko H. Zwinderman,Toine F. Cleo Book 2000 Springer Science+Business Media B.V. 2

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en, observations had been uncontrolled. Initially,trials frequently did not confirm the hypotheses to be tested. Thisphenomenon was attributed to low sensitivity due to small samples, aswell as inappropriate hypotheses based on biased prior trials.Additional flaws were recognized and, subsequently,

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https://doi.org/10.1007/978-94-015-9508-7Logistic Regression; correlation; linear regression; statistical inference; statistics

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Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism,efficacy responses; e.g. comparison of effects by age, sex; by severity or prognostic groups. Naturally, such analyses are not intended to “salvage” an otherwise negative study, but may be may be helpful in refining patient or dose selection for subséquent studies..