Titlebook: Statistics Applied to Clinical Trials; Ton J. Cleophas,Aeilko H. Zwinderman,Toine F. Cleo Book 2000 Springer Science+Business Media B.V. 2

GENUS

Interim Analyses,pursued appropriately by the investigators and to look at any difficulties, e.g., those with patient and/or doctor compliance, and to see whether there is any need for protocol alterations.. “Looking at the data” for such purposes should, however, be done carefully. In this chapter we will discuss questions such as:

Indolent

Book 2000ations had been uncontrolled. Initially,trials frequently did not confirm the hypotheses to be tested. Thisphenomenon was attributed to low sensitivity due to small samples, aswell as inappropriate hypotheses based on biased prior trials.Additional flaws were recognized and, subsequently, were bette

江湖郎中

Hypotheses, Data, Stratification,ve way of determining the relative efficacy and toxicity of new drug therapies. This course is mainly involved in the methods of prospective randomized clinical trials of new drugs. Other methods for assessment including open-evaluation-studies, cohort- and case-control studies, although sometimes u

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恶臭

直言不讳

抛媚眼

反对

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Meta-Analysis,uently have to be transformed into binary data for the purpose of comparibility; bad studies may be included; coverage may be limited; data may not be homogeneous; failure to relate data to hypotheses may obscure discrepancies. In spite of these well-recognized flaws, the method of meta-analysis is

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