Titlebook: Statistical Modeling in Biomedical Research; Contemporary Topics Yichuan Zhao,Ding-Geng (Din) Chen Book 2020 Springer Nature Switzerland A

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Molecular Basis of Food Classification in Traditional Chinese Medicine based on cold, neutral, and hot properties similar to Chinese herbal medicine. However, it is unclear whether such a classification has any molecular or biochemical basis, and what the relationship is between this TCM classification and the nutrient composition of food. To answer these questions, w

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Discovery Among Binary Biomarkers in Heterogeneous Populationstinct complex interactions among multiple biomarkers, and hence patients exhibit considerable heterogeneity in the biomarker-disease association despite sharing the same clinical diagnosis. Thus identification of clinically useful biomarker combinations requires statistical methods that accommodate

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Kernel Tests for One, Two, and ,-Sample Goodness-of-Fit: State of the Art and Implementation Consideiate two-sample goodness-of-fit tests from both statistics and machine learning literature. The review conducted delivers the fact that there does not exist a satisfactory multivariate two-sample goodness-of-fit test. We introduce a class of one and two-sample tests constructed using the kernel-base

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Hierarchical Modeling of the Effect of Pre-exposure Prophylaxis on HIV in the USan at-risk, susceptible individual acquiring HIV from an infected partner. The effectiveness of this preventative medication is dependent upon the population that uses it. Individuals susceptible to acquire HIV may engage in risky behaviors such as high partner number. We analyze the effectiveness o

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Weighted ,-Means Clustering with Observation Weight for Single-Cell Epigenomic Data single-cell chromatin accessibility data. The weight of noisy cells is tuned adaptively. In addition, we incorporate sparsity constraints in our proposed method for simultaneous clustering and feature selection. We also evaluated our proposed methods through simulation studies.

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