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Titlebook: Statistical Methods in Toxicology; Proceedings of a Wor Ludwig Hothorn Conference proceedings 1991 Springer-Verlag Berlin Heidelberg 1991 A

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书目名称Statistical Methods in Toxicology
副标题Proceedings of a Wor
编辑Ludwig Hothorn
视频video
丛书名称Lecture Notes in Medical Informatics
图书封面Titlebook: Statistical Methods in Toxicology; Proceedings of a Wor Ludwig Hothorn Conference proceedings 1991 Springer-Verlag Berlin Heidelberg 1991 A
描述This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX ‘90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.
出版日期Conference proceedings 1991
关键词ANOVA; Generalized linear model; Statistik; Toxikologie; evaluation; mutagen; research; statistics; toxicity
版次1
doihttps://doi.org/10.1007/978-3-642-48736-1
isbn_softcover978-3-540-53621-5
isbn_ebook978-3-642-48736-1Series ISSN 0172-7788
issn_series 0172-7788
copyrightSpringer-Verlag Berlin Heidelberg 1991
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Modern Statistical Methods in Toxicology — An overviewnd Lewi & Marsboom see Chambers, Chambers, 1981). During the past decade, a rapid development of statistical methods for toxicological studies could be observed. This development was supported by the standardization of several toxicological studies due to national (e.g., Bundeschemikaliengesetz, ano
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Statistical Analysis of the Micronucleus Test with the Fisher-Pitman Permutation Testor analysis is the number of micronucleated cells per animal in a predefined number of polychromatic erythrocytes. An increase in the frequency of micronucleated polychromatic erythrocytes relative to the controls indicates chromosomal damage induced by the substance under test.
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Tabular Overview of Statistical Methods Proposed for the Analysis of Ames , Assay Datapproaches proposed by various authors range from straightforward applications of classical linear models to more sophisticated statistical methods such as those of generalized linear models. The assay motivated the use of stochastic branching process theory for constructing the model equations to an
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Statistical Problems in Estimating a Threshold in a Dose-Response Model; Ehrenberg et al.,1983). However, the true shape of the dose-response curves for mutation and cancer at very low doses has been debated; e.g., the question of the existence or non-existence of a no-effect threshold is a subject of opposing opinions. This is partly a consequence of the fact that, fo
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