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Titlebook: Statistical Mechanics, Protein Structure, and Protein Substrate Interactions; Sebastian Doniach Book 1994 Springer Science+Business Media

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发表于 2025-3-21 18:09:12 | 显示全部楼层 |阅读模式
书目名称Statistical Mechanics, Protein Structure, and Protein Substrate Interactions
编辑Sebastian Doniach
视频video
丛书名称NATO Science Series B:
图书封面Titlebook: Statistical Mechanics, Protein Structure, and Protein Substrate Interactions;  Sebastian Doniach Book 1994 Springer Science+Business Media
描述A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence o
出版日期Book 1994
关键词Peptide; X-ray; development; mechanics; proteins
版次1
doihttps://doi.org/10.1007/978-1-4899-1349-4
isbn_softcover978-1-4899-1351-7
isbn_ebook978-1-4899-1349-4Series ISSN 0258-1221
issn_series 0258-1221
copyrightSpringer Science+Business Media New York 1994
The information of publication is updating

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Native-Like Intermediates in Protein Folding apocytochrome P450. melting is a two-state process. However, the enthalpy change at thermal melting is reduced from 980 kJ/mol for the holo protein to 135 kJ/mol for the apo form, and the apocytochrome P450cam stability amounts to ΔG = 7.5 kJ/mol..The apocytochromes are regarded as native-like prot
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Theoretical Perspectives on In Vitro and In Vivo Protein Folding. Since many proteins have been made to fold . it follows that the major principles of protein folding can be formulated without the need to involve extra cellular components. It therefore follows that the protein folding problem reduces to a statistical mechanical description of finite sized branch
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Constrained Langevin Dynamics of Polypeptide Chainses, with extensive runs on 20-alanine. We observe that poly-alanine has rather long-lived meta-stable configurations with partial beta sheet conformations which can live many hundreds of nano-seconds.
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Moil: A Molecular Dynamics Program with Emphasis on Conformational Searches and Reaction Path Calculno acids. Another example of repeating fragments is found in the base-pairs of DNA. The fragment solution is chemically intuitive, however, it is approximate. In general the intramolecular interactions in an amino acid are influenced by its neighborhood. For example the charge distribution is determ
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