书目名称 | Statistical Mechanics, Protein Structure, and Protein Substrate Interactions | 编辑 | Sebastian Doniach | 视频video | | 丛书名称 | NATO Science Series B: | 图书封面 |  | 描述 | A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence o | 出版日期 | Book 1994 | 关键词 | Peptide; X-ray; development; mechanics; proteins | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4899-1349-4 | isbn_softcover | 978-1-4899-1351-7 | isbn_ebook | 978-1-4899-1349-4Series ISSN 0258-1221 | issn_series | 0258-1221 | copyright | Springer Science+Business Media New York 1994 |
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