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Titlebook: Statin-Associated Muscle Symptoms; Paul D. Thompson,Beth A. Taylor Book 2020 Springer Nature Switzerland AG 2020 Clinical management of st

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Vitamin D and SAMS,f cardiovascular events. Statin-associated muscle symptoms are overwhelmingly the most commonly reported adverse effects of statin therapy and contribute to statin intolerance. The prevalence of vitamin D deficiency is increasing in many populations. Some available, mainly observational, studies hav
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Introduction,te about their very existence to the mechanisms causing them and the most effective way to diagnose and treat them. Improving our understanding of SAMS is critical for expanding use of statins to untreated adults, improving statin adherence, and directing patients with true statin intolerance to alternative cholesterol-lowering therapies.
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Large Clinical Trials of Statin-Associated Muscle Symptoms,n convertase subtilisin/kexin type 9 (PCSK9) activity and the effects of PCSK9 inhibitors (PCSK9i) have added significant opportunities for patients with SAMS. In this chapter we will cover the results and consequences of the PCSK9i trials and one other potential future therapy, bempedoic acid, for SAMS patients.
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