Titlebook: Statin-Associated Muscle Symptoms; Paul D. Thompson,Beth A. Taylor Book 2020 Springer Nature Switzerland AG 2020 Clinical management of st

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Prevalence of SAMS in Observational and Clinical Trials,ablishing the rate of SAMS in the statin-using population has been problematic. Both observational and clinical trials have produced widely disparate estimates of SAMS prevalence, due in part to methodological variance in patient selection, definition of SAMS, study design, and data collection techn

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Large Clinical Trials of Statin-Associated Muscle Symptoms,h as low-dose statins, or other lipid-modifying therapies (LMT) such as red yeast rice, ezetimibe, or berberine, have not proven to be an adequate alternative. Additionally, comprehensive clinical trials examining alternative therapy for SAMS are lacking. The discovery and understanding of proprotei

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The Effect of Statins on Exercise Performance and Exercise Training, statins on: (1) skeletal muscle strength, (2) aerobic exercise performance, (3) skeletal muscle and cardiac biomarkers during exercise, (4) training for athletic competition, and (5) physical activity adherence. The majority of evidence does not demonstrate a deleterious effect of statin therapy on

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Genetic Risk Factors for Statin-Associated Muscle Symptoms (SAMS), studies have identified various loci that seem to be associated with an increased risk of SAMS, but the statin-specific and phenotype-dependent association of simvastatin with .∗5 remains the most clinically relevant relationship. Lack of confirmatory data in replication cohorts and exclusion of in

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The Role of Muscle Protein and Energy Metabolism in Statin-Associated Muscle Symptoms,es in Akt/FOXO signalling. Forcibly increasing muscle carbohydrate flux under these conditions by pharmacological means blocks statin myopathy. Human volunteer research has delivered less definitive mechanistic insight of the aetiology of statin-related metabolic dysregulation, with little evidence