Titlebook: Staphylococcus aureus; Microbiology, Pathol Fabio Bagnoli,Rino Rappuoli,Guido Grandi Book 2017 The Editor(s) (if applicable) and The Author

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Staphylococcal Immune Evasion Proteins: Structure, Function, and Host Adaptation, proteins interfere with many critical components of the immune system, both innate and adaptive, and hamper proper immune functioning. In recent years, numerous studies have been conducted in order to understand the molecular mechanism underlying the interaction of evasion molecules with the host i

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Lysin Therapy for , and Other Bacterial Pathogens,sential bonds in the bacterial cell wall peptidoglycan for phage progeny release. Small quantities of purified recombinant lysin added externally to gram-positive bacteria results in immediate lysis causing log-fold death of the target bacterium. Lysins can eliminate bacteria both systemically and t

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Bacteremia, Sepsis, and Infective Endocarditis Associated with ,,to other pathogens. Central tenets of management include identification of complicated bacteremia, eradicating foci of infection, and, for many, prolonged antimicrobial therapy. Evolving multidrug resistance and limited therapeutic options highlight the many unanswered clinical questions and urgent need for further high-quality clinical research.

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Lysin Therapy for , and Other Bacterial Pathogens,ibiotics are their specificity for the pathogen without disturbing the normal flora, the low chance of bacterial resistance, and their ability to kill colonizing pathogens on mucosal surfaces, a capacity previously unavailable. Lysins, therefore, may be a much-needed anti-infective in an age of mounting antibiotic resistance.

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