Titlebook: Sphingolipids as Signaling and Regulatory Molecules; Charles Chalfant,Maurizio Del Poeta Book 2010 The Editor(s) (if applicable) and The A

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Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family,nderstanding of SM biosynthesis, starting from the discovery of SM to the identification of the enzymes responsible for its production; and second, at discussing old and new riddles that such discoveries pose to current investigators.

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Glucosylceramide in Humans,ncer. Overall, upregulation of glucosylceramide offers cellular protection and primes certain cells for proliferation. However, prolonged overabundance of glucosylceramide is detrimental, as seen in Gaucher disease in humans.

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Sphingolipid Transport, sphingolipid movements within and between membranes, focusing on the recent advances in this field and considering the role played by selective sphingolipid molecules in the regulation of these mechanisms.

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Sphingolipid Analysis by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/Mneous qualitative and quantitative monitoring of SPL components (classes and molecular species) in biological material as an effective tool to study sphingolipid signaling events. The LC-MS/MS methodology is the only available technique that provides high specificity and sensitivity, along with a wealth of structural identification information.

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Roles for Sphingolipids in ,, uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.

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Animal Models for Studying the Pathophysiology of Ceramide,nt and disease. In this chapter, we review the phenotypes of GEM models (knockout mice) that lack sphingolipid metabolism-related enzymes, discuss what we have learned from animal models and describe future directions of animal models in sphingolipid research.

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Biosynthesis of Sphingolipids in Plants (and Some of Their Functions),ew insights into sphingolipid functions. Very little is still known about intracellular transport, spatial distribution, degradation and signaling functions of sphingolipids. However, combination of . genetics with lipidomics and cell biology will soon bring our understanding of these issues to a new level.