Titlebook: Sphingolipid Metabolism and Metabolic Disease; Xian-Cheng Jiang Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive

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Sphingosine 1-Phosphate Metabolism and Signaling,binds to receptors provoking the downstream signaling cascades in distinct cells. This chapter will review the synthesis, degradation, transportation, and signaling of S1P and try to provide a comprehensive view of the biology of S1P, evoking new enthusiasms and ideas into the field of the fascinating S1P.

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intrigue

De Novo Sphingolipid Biosynthesis in Atherosclerosis,athological processes, including myocardial infarction and stroke. Dyslipidemic conditions with excess cholesterol accumulate within the arterial vessel wall and initiate atherogenic processes. Following vascular reaction and lipid accumulation, the vascular wall gradually thickens. Together with th

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Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases,a long chain base (LCB) as the common structural element, which is typically formed by the condensation of .-serine and long chain acyl-CoA. This condensation is the first and the rate-limiting step in the de novo SL synthesis and catalyzed by the enzyme serine palmitoyltransferase (SPT). Although p

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Sphingosine 1-Phosphate Metabolism and Signaling,of key enzymes involved in generation of S1P have been identified and characterized in detail, as well as enzymes degrading S1P. S1P requires transporter to cross the plasma membrane and carrier to deliver to its cognate receptors and therefore transduces signaling in autocrine, paracrine, or endocr