| 书目名称 | Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes | | 编辑 | Lena Josefine Daumann | | 视频video | | | 概述 | Nominated as an Outstanding Ph.D. thesis by the University of Queensland, Australia.Encompasses a broad range of topics including biochemical, kinetic and mechanistic studies, chemical synthesis, as w | | 丛书名称 | Springer Theses | | 图书封面 |  | | 描述 | Lena Daumanns‘s thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and β-lactams. Overall, this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section. | | 出版日期 | Book 2014 | | 关键词 | Antibiotic Resistance; Bioinspired Hydrolysis; Biomimetic Complex; Dinuclear Cobalt Complexes Magnetism | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-06629-5 | | isbn_softcover | 978-3-319-36098-0 | | isbn_ebook | 978-3-319-06629-5Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | Springer International Publishing Switzerland 2014 |
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发表于 2025-3-21 18:45:46
