| 书目名称 | Somatic Diversification of Immune Responses |
| 编辑 | Garnett Kelsoe,Martin F. Flajnik |
| 视频video | |
| 概述 | As knowledge from experimentation accumulates, we begin to have a somewhat clearer picture of the muation/conversion process(es)..This volume takes one step forward in the analysis of somatic diversif |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator‘s action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.‘s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist‘s preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem. |
| 出版日期 | Book 1998 |
| 关键词 | Antigen; Antikörper; antibody; cell; development; evolution; gene; genetics; immune response; immunity; immuno |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-71984-4 |
| isbn_softcover | 978-3-642-71986-8 |
| isbn_ebook | 978-3-642-71984-4Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 16:58:29
