Titlebook: Small Molecule Therapeutics for Schizophrenia; Sylvain Celanire,Sonia Poli Book 2015 Springer International Publishing Switzerland 2015 5H

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Apogee

潜移默化

声明

1862-2461 to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.978-3-319-37894-7978-3-319-11502-3Series ISSN 1862-2461 Series E-ISSN 1862-247X

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,Antipsychotics and the Dopamine–Serotonin Connection,y and pathophysiology, as well as the underlying neurobiological substrate are still a matter of intense research and controversy. In the early 1950s of the previous century, a major revolution took place in the treatment of schizophrenia: the introduction of chlorpromazine (.) and in its wake a ser

BRAWL

一再遛

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Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associateposed as a potential therapeutic strategy for treating these diseases. This chapter describes the recent progress in the discovery and development of mGlu. positive allosteric modulators (PAMs) as a novel therapeutic approach which does not involve a direct interaction with dopamine receptors. This

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Nicotinic Acetylcholine Receptor Modulators,r delivery form of cigarettes at a significantly higher incidence than the general population (80–90% vs. 25–30% of the general population) and even than those diagnosed with other psychiatric diseases. Various studies have demonstrated that cigarette smoking transiently restores cognitive and senso