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Titlebook: Small Molecule Therapeutics for Schizophrenia; Sylvain Celanire,Sonia Poli Book 2015 Springer International Publishing Switzerland 2015 5H

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发表于 2025-3-21 16:06:59 | 显示全部楼层 |阅读模式
书目名称Small Molecule Therapeutics for Schizophrenia
编辑Sylvain Celanire,Sonia Poli
视频video
概述Overview chapters introduce the newcomer to the topic covered.Series covers hot topics of frontier research summarized by reputed scientists in the field.Volumes are useful and of relevance for a long
丛书名称Topics in Medicinal Chemistry
图书封面Titlebook: Small Molecule Therapeutics for Schizophrenia;  Sylvain Celanire,Sonia Poli Book 2015 Springer International Publishing Switzerland 2015 5H
描述The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.
出版日期Book 2015
关键词5HT Receptor Ligands; DA Receptor Ligands; GLYT1 Inhibitors; PDE10/PDE9 Inhibitors; mACh Activators; mGlu
版次1
doihttps://doi.org/10.1007/978-3-319-11502-3
isbn_softcover978-3-319-37894-7
isbn_ebook978-3-319-11502-3Series ISSN 1862-2461 Series E-ISSN 1862-247X
issn_series 1862-2461
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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978-3-319-37894-7Springer International Publishing Switzerland 2015
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,Antipsychotics and the Dopamine–Serotonin Connection,ly slightly improved this situation. The vast majority of antipsychotics bind to dopamine as well as serotonin receptors, and it has been suggested that the ratio between the affinities for these receptors may be crucial for the therapeutic properties. The aim of the present review is to evaluate th
发表于 2025-3-22 20:59:31 | 显示全部楼层
GlyT-1 Inhibitors: From Hits to Clinical Candidates,T ligand development and their use in clinical development and the status of clinical-stage compounds will be addressed. Finally there is a discussion of some of the issues that have arisen with the discovery and development of GlyT-1 inhibitors and the prospects for the future of this mechanistic a
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Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associatehesis of schizophrenia. The fine tuning of the functional activity and the clarification of biased signaling pathways in different chemical series may provide clues to achieve efficacy and a good safety profile for novel pharmacotherapies.
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