Titlebook: Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration; Sung-Tsang Hsieh,Praveen Anand,Claudia Sommer Book 2019 Springer

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Neurophysiological Assessments in Small Fiber Neuropathy: Evoked Potentialsental pain. Laser-evoked potentials (LEPs) are obtained after rapid heating of the skin with laser pulses, can help to identify lesions of small sensory nerve fibers and/or their CNS pathways, and represent a sensitive, objective, and noninvasive method for the assessment of SFN. Contact heat-evoked

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Diabetes-Related Neuropathiesn from a distal symmetric neuropathy, mononeuropathy, cranial neuropathy, plexus neuropathy, or even autonomic neuropathy. In this chapter, the clinical presentation, diagnosis, and management of the various diabetes-related neuropathies are reviewed.

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Amyloid NeuropathyAL amyloidosis is due to B-cell dyscrasia, treatments include (1) a combination of prednisolone and chemotherapy (melphalan) and (2) target therapy of proteasome inhibitor (e.g., bortezomib). TTR-FAP is the most common genotype of FAP compared with other amyloid-producing genes (gelsolin and apolipo

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Small Fiber Pathology in Pain Syndromesme (FMS) is characterized by chronic widespread pain, mostly localized to deep tissues, and associated symptoms like morning stiffness, depression, and unrefreshing sleep. The finding of small fiber pathology in the skin in these patients was unexpected; however, it was independently confirmed by re

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Visceral Pain and Hypersensitivity Disordersnerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF), are known to regulate nociceptor function in health and disease; overexposure of nociceptors to neurotrophic factors is a key underlying mechanism in a number of chronic visceral pain syndromes, including irritable bowel sy