Titlebook: Skeletal Development and Repair; Methods and Protocol Matthew J. Hilton Book 2021Latest edition Springer Science+Business Media, LLC, part

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A Mouse Femoral Ostectomy Model to Assess Bone Graft Substitutesbone regenerative potential of bone graft substitutes to be investigated. Lastly, we provide instruction on assessing the torsional strength of the healed femurs to quantitatively evaluate the degree of healing as a primary outcome measure.

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Overview of Skeletal Developmenttogenic cells, including chondrocytes and osteoblasts. These cells differentiate from common progenitor cells originating in the mesoderm and neural crest. Multiple signaling pathways and transcription factors tightly regulate differentiation and proliferation of skeletal cells. In this chapter, we

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Advantages and Limitations of Cre Mouse Lines Used in Skeletal ResearchIt has allowed tremendous advances in our understanding of skeleton biology and related pathophysiological mechanisms, through the generation of loss/gain of function or cell tracing experiments based on the creation of an expanding toolbox of transgenic mice expressing the Cre recombinase in skelet

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Generation of Closed Transverse Fractures in Small Animalsesses that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented and general considerations when setting up an experiment using this model are describe

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A Mouse Femoral Ostectomy Model to Assess Bone Graft Substitutes have been developed as bone graft substitutes each with their own advantages and disadvantages. However, in order to test if these biomaterials provide an adequate replacement of the clinical standard, a clinically representative animal model is needed to test their efficacy. In this chapter, we de

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Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton Within this chapter, we present a protocol for parabiosis, a surgical model which results in shared circulation between two mice. Such chimeras have recently been used to probe the impact of age-associated changes in the circulation on skeletal, muscular, and neural biology. In conjunction with tra