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Titlebook: Sildenafil; Udo Dunzendorfer Book 2004 Springer Basel AG 2004 biochemistry.cancer.chemistry.development.drug.endothelium.erectile dysfunct

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Therapy of erectile dysfunction (ED) with sildenafil improves quality of life (QoL) and partnershipularly physiological levels of functioning are satisfactory and healthy (Fig. 1). Satisfactory partnership and sexuality are core aspects of human wellbeing through the complete course of adulthood. Sexual activity is a major determinant of sexual satisfaction [.]. In men and women, sexual dysfuncti
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Erectile dysfunction, depression, and pharmacological treatments: biologic interactions,with a range of imputed neurobiological, medical, psychological and interpersonal causes, and can have a significant impact on interpersonal functioning and quality of life. Moreover, the interaction between co-morbid sexual and psychiatric disorders has clinical implications for diagnosis, course,
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Potential role for the PDE5 inhibitor sildenafil in the treatment of female sexual dysfunction,pausal women, organic underlying causes that could be susceptible to pharmacologic or surgical treatment have only recently been considered [.]. In the last decade significant discoveries in the biochemistry, physiology and pharmacology of male sexual function have led to marked improvements in the
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Molecular processing of sildenafil in endothelial function: potential applications in cardiovasculaduction of the second messenger cyclic guanosine monophosphate (cGMP) via the activation of the heme-containing protein soluble guanylate cyclase in vascular smooth muscle [.–.]. In vascular smooth muscle, cGMP mediates its vasorelaxation effects by activation of cGMP-dependent protein kinase (PKG),
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Cardiovascular safety of sildenafil in the treatment of erectile dysfunction,lar diseases. These reports have raised serious concerns about the cardiovascular safety of PDE5 inhibitors, and several investigations have addressed this issue in the past few years. These studies have concordantly shown that the use of sildenafil is safe in patients with stable cardiac diseases.
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