Titlebook: Signal Transduction by G Protein-Coupled Receptors; Bioenergetics and G Paul H. J. Nederkoorn,Henk Timmerman,Gabriëlle M. Book 1997 Sprin

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G Protein-Coupled Receptors and G Proteins of chemical ligands or photons (in the case of opsins). Once the external signal is received, it is transduced to a cytosolic G protein. Subsequently, the G protein itself becomes activated. Hundreds of GPCRs have been sequenced, and they have been classified into three superfamilies:. (i) rhodopsi

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A New Mechanism for G Protein Activationbundant and the system is therefore deal for studying G protein activation. Throughout, we assume that findings for one particular type of G protein present in a certain species and tissue can be used to infer the activation mechanism or G proteins in general. Within the new model, all experimental

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Principles of a New Molecular Mechanism for Signal Transductionre insights in the several processes involved than the classical theory does. In the previous chapter, we have described schematically a new model for G protein activation. We will end by presenting five postulates on the manner in which GPCRs and G proteins act in this new model, incorporating the

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Conclusions and Future Perspectives mediated via (ligand-induced) GPCR and G protein activation. The classical model for G protein activation is based on an exchange mechanism followed by GTP hydrolysis. Our new model is based on GTP synthesis from GDP and P., also followed by GTP hydrolysis. Because of amplification levels (1) (synt

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