| 书目名称 | Signal Transduction and the Coordination of B Lymphocyte Development and Function I |
| 副标题 | Transduction of BCR |
| 编辑 | Louis B. Justement (Associate Professor),Katherine |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism‘s ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B c |
| 出版日期 | Book 2000 |
| 关键词 | Activation; Antigen; cell; cell biology; cell membrane; cytoskeleton; gene; gene expression; lymphocytes; mem |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-57066-7 |
| isbn_softcover | 978-3-642-63017-0 |
| isbn_ebook | 978-3-642-57066-7Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 18:23:26
