Titlebook: Sigma Proteins: Evolution of the Concept of Sigma Receptors; Felix J. Kim,Gavril W. Pasternak Book 2017 Springer International Publishing

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Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors,amily, molecular studies have now identified its genes and established its structure crystallographically. Much effort has now revealed its importance as a chaperone in the endoplasmic reticulum, but its functions extend beyond this. Sigma. receptors have been associated with a host of signaling sys

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A Role for Sigma Receptors in Stimulant Self-Administration and Addiction,rs of psychomotor stimulant effects and have at times been proposed as potential avenues for modifying stimulant abuse. However, the influence of ligands for σRs on the effects of stimulants, such as cocaine or methamphetamine, in various preclinical procedures related to drug abuse has been varied.

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Sigma1 Pharmacology in the Context of Cancer,. The majority of publications on the subject have focused on the neuropharmacology of Sigma1. However, a number of publications have also suggested a role for Sigma1 in cancer. Although there is currently no clinically used anti-cancer drug that targets Sigma1, a growing body of evidence supports t

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Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies,y and high selectivity for σ. receptors have the potential to assess the proliferative status of human tumors using noninvasive imaging techniques such as Positron Emission Tomography (PET). Since the σ. receptor has not been cloned, the current knowledge of this receptor has relied on receptor bind

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Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors,ite the large number of publications regarding Sigma1, several fundamental questions remain unanswered or only partially answered. Most of what we know about Sigma1 comes from pharmacological studies; however, a clearly defined molecular mechanism of action remains elusive. One concept has become cl

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