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Titlebook: Side-Effects of Anti-Inflammatory Drugs; Part Two Studies in K. D. Rainsford,G. P. Velo Book 1987 MTP Press Limited 1987 Arthritis.Glucoco

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Evidence for sulphydryl-sensitive process in the mechanisms of acute gastric mucosal injury and defeoses of prostaglandins (PGs) resulted in a revival of interest in studying the mechanisms of gastric and intestinal mucosal injury and defence. In addition to the initially described protective effect of PGs, various other drugs such as sodium salicylate (studied by Ezer et al.. and Robert. and sulp
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Both E Prostaglandins and prolonged indomethacin treatment exert trophic effects on the gastric muco was first shown in our laboratories, when rats were treated with high doses of metiamide, a precursor of cimetidine.. It was later confirmed with cimetidine. and was subsequently also observed with prolonged antacid treatments.. In all these studies a hyperplasia of the parietal cells was observed.
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Mechanisms of gastric contrasted with intestinal damage by non-steroidal anti-inflammatory drugscase of the osmotic slow-release formulation of indomethacin (Osmosin) and for indoprofen. (Flosint) as to necessitate their withdrawal recently. There has also been concern that some NSAIDs with potent actions as inhibitors of prostaglandin (PG) synthesis might exacerbate inflammatory bowel diseases (IBDs)..
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