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Titlebook: SialoGlyco Chemistry and Biology II; Tools and Techniques Rita Gerardy-Schahn,Philippe Delannoy,Mark von Itz Book 2015 Springer Internation

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书目名称SialoGlyco Chemistry and Biology II
副标题Tools and Techniques
编辑Rita Gerardy-Schahn,Philippe Delannoy,Mark von Itz
视频video
概述Overview chapters introduce the newcomer to the topic covered.Series covers hot topics of frontier research summarized by reputed scientists in the field.Volumes are useful and of relevance for a long
丛书名称Topics in Current Chemistry
图书封面Titlebook: SialoGlyco Chemistry and Biology II; Tools and Techniques Rita Gerardy-Schahn,Philippe Delannoy,Mark von Itz Book 2015 Springer Internation
描述The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume ed
出版日期Book 2015
关键词Endosialidases; Lectin microarray; SIGLEC4 Antagonists; Sialic Acid Receptors; Sialo-N-linked glycans; Si
版次1
doihttps://doi.org/10.1007/978-3-319-21317-0
isbn_softcover978-3-319-37370-6
isbn_ebook978-3-319-21317-0Series ISSN 0340-1022 Series E-ISSN 1436-5049
issn_series 0340-1022
copyrightSpringer International Publishing Switzerland 2015
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Endosialidases: Versatile Tools for the Study of Polysialic Acid,eriophage-borne glycosyl hydrolases that specifically cleave polysialic acid. The crystal structure of an endosialidase reveals a trimeric mushroom-shaped molecule which, in addition to the active site, harbors two additional polysialic acid binding sites. Folding of the protein crucially depends on
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Development and Applications of the Lectin Microarray,procedures for differential glycan profiling in a rapid and high-throughput manner. Since its first appearance in the literature in 2005, many application methods have been developed essentially on the same platform, comprising a series of glycan-binding proteins immobilized on an appropriate substr
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Sialoside Arrays: New Synthetic Strategies and Applications,ctions, the immune response, the progression of tumor cell metastasis, etc. Despite the importance, the limited access to complex sialosides had prevented extensive studies on the function and significance of sialic acid structural diversity. However, recent advances in synthetic sialoside chemistry
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SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics,binds with high preference to sialic acids α(2–3)-linked to .-galactose. Although the involvement and relevance of its sialic acid binding activity is still controversial, it could be demonstrated that interactions of MAG with sialylated gangliosides play an important role in axon stability and rege
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