Titlebook: Serpins; Methods and Protocol Alexandra Lucas Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Serine protease

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Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing,aves the RCL, the serpin and protease become covalently linked leading to a loss of function of both the protease and the serpin; this suicide inhibition is often referred to as a “mouse trap.” When the RCL P1-P1′ scissile bond is cut by the protease, the resulting bond between the protease and the

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Methods for Assessing Serpins as Neuroprotective Therapeutics,ordinarily protracted, destructive inflammation follows the initial injury. Appropriate anti-inflammatory therapies of sufficient duration should not only inhibit but also lead to the elimination of this destructive inflammation, thus resulting in neuroprotection of the spinal cord tissue and a grea

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Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation,inical trials. This viral vector has a 4.7 kbp (kilo base pair) carrying capacity (single-stranded DNA) and only retains the inverted terminal repeats (ITRs) from the original virus. Here we describe the design and testing of AAV vectors capable of delivering an anti-inflammatory .ine .rotease .hibi

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Serpins: Development for Therapeutic Applications,n and breakdown, immune responses, lung function, and hormone or central nervous system activity, among many others. When serine protease activity or serpin-mediated regulation becomes unbalanced or dysfunctional, then severe disease states and pathogenesis can ensue. With serpinopathies, genetic mu

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