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Titlebook: Serpins; Methods and Protocol Alexandra Lucas Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Serine protease

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发表于 2025-3-21 19:55:01 | 显示全部楼层 |阅读模式
书目名称Serpins
副标题Methods and Protocol
编辑Alexandra Lucas
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Serpins; Methods and Protocol Alexandra Lucas Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Serine protease
描述This volume explores the latest methods used to study and define serpin molecular structure, basic protease inhibition, serpin targets, and the roles of serpin in biology and disease using animal models. The chapters in this book cover topics such as crystallography and phage display, peptide design, phospholipid binding, and thrombus formation to microbiome analysis and development. Written in the highly successful .Methods in Molecular Biology. series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls..Cutting edge and authoritative, .Serpins: Methods and Protocols. is a valuable resource for researchers and scientists interested in learning more about this evolving field..
出版日期Book 2018
关键词Serine protease inhibitors; Regulatory drugs; Inhibitory agents; Therapeutic design; Enzyme inhibition a
版次1
doihttps://doi.org/10.1007/978-1-4939-8645-3
isbn_softcover978-1-4939-9352-9
isbn_ebook978-1-4939-8645-3Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2018
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Methods in Molecular Biologyhttp://image.papertrans.cn/s/image/865499.jpg
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Alexandra LucasIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
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Cellular Models for the Serpinopathies,have been extensively modeled in cell culture systems by expressing mutant variants in a variety of ways. Here we describe the methodologies we follow in our cell model systems used to examine serpin disorders.
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Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing,sert their RCL into adjacent serpins forming aggregates of inactive serpins..We have further posited that this natural cleavage site in the serpin RCL may form active serpin metabolites with potential to add to the serpin’s inhibitory functions. We have developed RCL peptides based upon predicted se
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