Titlebook: Serotoninergic Neurons and 5-HT Receptors in the CNS; H. G. Baumgarten,M. Göthert Book 2000 Springer-Verlag Berlin Heidelberg 2000 CNS.Ner

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Molecular Biology and Potential Functional Role of 5-HT5, 5-HT6, and 5-HT7 Receptors,ng, including the discovery of “novel” receptor subtypes such as 5-HT., 5-HT., 5-HT., and 5-HT.. All four subtypes are members of the G-proteincoupled receptor (GPCR) superfamily. Detailed characterization of the pharmacological profiles of these cloned receptor subtypes facilitates the interpretati

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Electrophysiology of 5-HT Receptors,ligand binding and functional studies (e.g., 5-HT., 5-HT., 5-HT., 5-HT.), represent separate and distinct gene products. This knowledge has had a crucial impact on electrophysiological approaches to the 5-HT system in two important ways: (1) studies on previously . 5-HT receptors are now being direc

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Molecular Biology and Transductional Characteristics of 5-HT Receptors, adenylate cyclase, phosphoinositide turnover, and potassium channel modulation) which exhibit time constants in the second to millisecond range, consistent with broad signal modulation and gain-setting functions in the brain.

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Development and Adult Plasticity of Serotoninergic Neurons and Their Target Cells,l connections. We once spoke of the trophic role serotonin plays in brain development prior to the time it assumes its role as a neurotransmitter in the mature brain. Now we speak of the role serotonin plays throughout the life of the brain, as a Factor regulating both the maintenance and plasticity of mature neuronal and glial phenotypes.

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Physiology and Pharmacology of Brain Serotoninergic Neurons,bes our research efforts in three subject areas:.Overall, this research has provided us with a unique perspective for drug action on the CNS serotoninergic system and, more broadly, on the basic role of serotonin in physiology and behavior.

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