Titlebook: Serotonin; Current Aspects of N Bernard Haber,Sabit Gabay,S. G. A. Alivisatos Book 1981 The Editor(s) (if applicable) and The Author(s), un

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Influence of Plasma Tryptophan on Brain 5HT Synthesis and Serotonergic Activity influenced by the supply of tryptophan to the brain. This is indicated by:.In rat experiments, determinations of brain tryptophan uptake from a bolus of plasma injected into the carotid artery showed:.Plasma total tryptophan could be rapidly decreased and free tryptophan increased by briefly distur

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Tryptophan Availability and the Control of 5-Hydroxytryptamine and Tryptamine Synthesis in Human CNSthe rate-limiting enzyme in 5HT synthesis, tryptophan hydroxylase, is not normally saturated with tryptophan (Friedman et al., 1972). This is important physiologically as amounts of tryptophan as small as one twentieth of a rat’s normal daily intake can result in a significant rise of plasma and bra

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Studies on the Oxygen Sensitivity of Tryptophan Hydroxylaseg step in the biosynthesis of the neurotransmitter serotonin (Jequier et al, 1967). Since the discovery of this enzyme in extracts of brain tissue (Lovenberg et al, 1967; Gal et al, 1966, Grahame-Smith, 1964) relatively little progress has been made in delineating its physical properties and kinetic

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Influence of Histamine on Serotonin Metabolism in Rat Braingress has been made in the study of possible interaction between different amines, among them a relationship between histamine (HI) and serotonin (5HT) systems in mammals. Bevan et al. (1975) showed that noncontractile doses of HI can augment contractile responses of 5 HT in the isolated rabbit basi

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Serotonin and Dopamine Synthesis in Phenylketonuria serotonin and dopamine biosynthesis is inhibited by high L-phenylalanine in blood and tissues. The dopamine formation in vivo was inhibited by phenylalanine blood concentrations higher than 25 mg/dl: the serotonin formation was inhibited even at a phenylalanine blood concentration of only 8 mg/dl..

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Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotonergic Neurony reserpine, and the characteristic dependence of SBP on Fe. for 5-HT binding enable SBP to be recognized (Tamir et al., 1976). The 5-HT-Fe.-SBP complex has a mobility on 10% SDS-polyacrylamide gels corresponding to 60,000 daltons (figure 1).

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Influence of Histamine on Serotonin Metabolism in Rat Braintors. In our laboratory it was shown that HI-induced hypothermia in the rat was significantly reduced by both histamine H.-receptor and 5HT receptor antagonists, CIM and metergoline, respectively; by cyproheptadine, possessing anti-histamine H.-receptor and anti-5HT receptor activities, by PCPA, which impairs 5HT synthesis (Pilc and Nowak, 1979).