Titlebook: Sequence — Evolution — Function; Computational Approa Eugene V. Koonin,Michael Y. Galperin Textbook 2003 Springer Science+Business Media Do

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Genome Annotation and Analysis,otein sequences. Here, we turn to one of the main subjects of this book, namely how these methods are applied to the task of primary analysis of genomes, which often goes under the name of “genome annotation”. Many researchers still view genome annotation as a notoriously unreliable and inaccurate p

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Evolution of Central Metabolic Pathways: The Playground of Non-orthologous Gene Displacement,have been obtained. As discussed in Chapter 1, there is no chance that all necessary biochemical experiments are ever done in any substantial number of organisms. Therefore reconstructions made through comparative genomics, combined with the knowledge derived from experiments on model systems, are t

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Evolutionary Concept in Genetics and Genomics,strations that any expectation based solely on family history should be taken with a grain of salt. Nevertheless, absent other clues to the character of the subject in question, an educated guess could be made based on the family structure and the individual’s position within that structure.

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Evolution of Central Metabolic Pathways: The Playground of Non-orthologous Gene Displacement,he only realistic path to a satisfactory understanding of the biochemical diversity of life and to the characterization of poorly studied and hard-to-grow organisms (including extremely important ones, e.g. the syphilis spirochete . [243,887]).