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Mohit Sewak,Sanjay K. Sahay,Hemant Rathore causes of death for young adults (<30 years of age) in the United States. Trauma represents a severe form of injury including bone fracture, penetrating soft tissue injury, (i.e., gunshot wounds), thermal injury and protracted surgical procedures. Many forms of traumatic injury, such as penetrating

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e past two decades. However, morbidity and mortality still occur due to a wide variety of complications in the setting of trauma and major surgery. One of the foremost of these complications is continued blood loss [1, 2]. Despite best surgical practice ongoing bleeding from sites of major trauma an

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Sherifdeen Lawal,Ram Krishnane past two decades. However, morbidity and mortality still occur due to a wide variety of complications in the setting of trauma and major surgery. One of the foremost of these complications is continued blood loss [1, 2]. Despite best surgical practice ongoing bleeding from sites of major trauma an

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is probably due to the effect of distinct mechanisms over time [.–.]. Early in the course of the disease, a massive release of inflammatory mediators (normally designed to trigger an immune response against pathogens) is occurring that may be responsible for organ dysfunction and hypoperfusion [.,

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