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Titlebook: Sarcoidosis; J. G. Scadding,D. N. Mitchell Book 1985 Scadding and Mitchell 1985 immunology.inflammation.muscle.pathogenesis.pathology.skin

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Historical Survey,without skin involvement. Some of the names at first used for this systemic disease were derived from those used for the skin eruptions and others were eponyms, based upon claims for priority of description (Scadding, 1981a).
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Ocular Changes,y deposition of calcium salts in the bulbar conjunctiva and in the cornea (band keratopathy) in patients with hypercalcaemia, by involvement of the lacrimal sac and duct, and by infiltration of the orbital fat causing exophthalmos.
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The Liver, patients in whom the diagnosis of sarcoidosis is not readily evident from involvement of other organs, a wide range of diseases in which granulomatous changes may be found in the liver must be considered in differential diagnosis.
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The Gastro-intestinal tract,nly clinically evident site of granulomatous disease, unequivocal diagnostic categorization may be difficult or impossible. In the small gut, a special difficulty arises in relation to Crohn’s disease, because of the granulomatous component in the histopathology of many cases and of some immunological features which it shares with sarcoidosis.
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Pathology, defined as a chronic inflammatory response in which cells of the mononuclear phagocyte series are prominent, usually forming focal aggregations (Williams and Williams, 1983). When these are well-marked, they are recognizable as tubercles. Knowledge of this sort of inflammation started from the stud
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Definition,ws that they have several different sorts of factual implication. Thus the medical concept ‘a disease’ is logically heterogeneous, though this is not generally recognized (Scadding, 1959, 1963, 1972, 1981b; Campbell ., 1979). Historically, this heterogeneity has arisen because the characteristics by
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Prevalence, Incidence and Modes of Presentation,e discovered at screening examinations and follow an asymptomatic course to resolution, it is certain that in the general community many individuals must pass through the whole course of the disease without consulting a doctor. Another is that clinical diagnosis is in some cases a matter of judgemen
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