Titlebook: SCF and APC E3 Ubiquitin Ligases in Tumorigenesis; Hiroyuki Inuzuka,Wenyi Wei Book 2014 The Author(s) 2014 E3 ubiquitin ligase.F-box prote

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The Role of APC E3 Ubiquitin Ligase Complex in Tumorigenesis,08), while the overexpression of Cdc20 is observed in human malignancies (Mondal et al., Carcinogenesis 28(1):81–92, 2007; Jiang et al., Biochem Biophys Res Commun 415(2):325–329, 2011; Rajkumar et al., BMC Cancer 11:80, 2011; Chang et al., J Hematol Oncol 5:15, 2012; Kato et al., J Surg Oncol 106(4

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Conclusions and Research Perspectives,ategies to efficiently identify novel substrates for each E3 ligase, and to establish additional genetically engineered mouse models, both of which would greatly facilitate our understanding of the physiological as well as pathological roles of SCF and APC in tumorigenesis (Fig. 6.1).

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Book 2014mor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key c

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Introduction,ulated responses to physiological cues that regulate normal cellular processes including proliferation, survival, and differentiation. Intensive investigations over the past decades have demonstrated that cancer can be considered largely a genetic disease, and typically multiple genetic alteration e