Titlebook: Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy; Etienne Baulieu,Donald T. Forman,James L. Wittliff Conference pro

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Chemical, Biological and Antitumor Properties of Ruthenium(II) Complexes with Dimethylsulfoxide,d chemical behavior of the two complexes are dscribed and related to their interactions with DNA and their antitumor properties. A tentative scheme of the mechanism of action of the two isomers is also reported.

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Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes,ments have quantified the effect of these different lesions on DNA replication, their capacity to induce mutations and their susceptibility to DNA repair processes. Additional DNA damage may be created by platinum(IV) compounds, perhaps during their reduction to platinum(II) compounds by the cell.

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Ruthenium Chemistry Pertaining to the Design of Anticancer Agents,diagnostic imaging, and, c) most recently, radiosensitizers for radiotherapy. With regard to chemotherapeutic agents, complexes with nitrogen ligands and anionic leaving groups appear to be the most active as cytotoxic agents, with nuclear DNA usually assumed as the target site. Binding to DNA may o

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Metal Complexes as Radiosensitizers,clinical relevance due to the inherent radioresistance of a tumor hypoxic fraction. Selective attack on hypoxic cells may also be achieved by development of hypoxic cytotoxins and chemosensitizers, which may act by enhancing the hypoxic toxicity of other agents. In radiosensitization three principal