| 书目名称 | Role of the Transcriptome in Breast Cancer Prevention |
| 编辑 | Jose Russo,Irma H. Russo |
| 视频video | http://file.papertrans.cn/832/831563/831563.mp4 |
| 概述 | Provides new insight on cancer prevention based on meticulously researched processed that have been gleaned from basic to translational research with a direct clinical application.Targeted to the medi |
| 图书封面 |  |
| 描述 | This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy isa protective factor in human against breast cancer and they have used this paradigmand developed experimental systems in both in vivo and in vitro that have demonstrated mechanisticallyhow the differentiation at the organ andcellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in thebreast that differs according to the reproductive historyof the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The |
| 出版日期 | Book 2013 |
| 关键词 | Breast; Breast Cancer; Cancer; Cancer Research; Prevention |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-4884-6 |
| isbn_softcover | 978-1-4899-8993-2 |
| isbn_ebook | 978-1-4614-4884-6 |
| copyright | Springer Science+Business Media New York 2013 |
|Archiver|手机版|小黑屋|
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