Titlebook: Role of Transcription Factors in Gastrointestinal Malignancies; Ganji Purnachandra Nagaraju,Pallaval Veera‘Bramhac Book 2017 Springer Natu

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Role and Regulation of Transcriptional Factors in Gastric Cancer, species induce, amplify, and sustain inflammation (in the lining of the stomach) in the host. Signalling pathways like β-catenin, NF-κB, etc. bring about changes in the genetic material leading to diversification of genetic material. Genetic diversification in oncogenes and tumour suppressor genes

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Role of Hypoxia-Inducible Factor (HIF) in the Initiation of Cancer and Its Therapeutic Inhibitors,or (HIF) facilitates the cellular response to hypoxia. HIF, a heterodimer composed of two subunits, the subunit α and subunit β, is involved in several signaling pathways which involves both survival and death pathways, their activation and regulation. HIF is believed to be the best molecular target

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Activation of STAT3 in Gastric Cancer Development,and cytokines regulate homeostasis of both epithelial and stromal cells. Deregulation of STAT3 activation is important in the initiation of transformation of various cancers that are epithelial in origin. This chapter mainly focuses on STAT3 activation in gastric cancer and its progression with the

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Role of STAT3 in Gastric Cancer Initiation, Development, and Progression,in terms of manifestation. Annual gastric cancer manifestations are reaching several millions of deaths along with millions of new cases. Gastric cancer which is not detected in the early stages has very poor prognosis, and the 5-year survival rate is only around 20%. Gastric cancer development incl

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,Curcumin: Its Role in Regulation of HIF-1α in Gastric Cancer,ic cancer, associated with tumor invasion and metastasis. Under hypoxic conditions, cancer cells start their own adaptive pathways to have a facilitated oxygen and energy supply for survival. In this condition, hypoxia-inducible factors (HIF) such as HIF-1α have a vital role particularly in cellular

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Activator Protein-1 Transcription Factors in Pathological Cancers,iption factors driving the progression of cancer, there is still a knowledge gap in the process of better understanding the molecular mechanisms controlled by AP-1 transcription factors during cancer advancement. ., we have evaluated the role of transcription factors which provides new insights into

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