书目名称 | Role of Proteases in the Pathophysiology of Neurodegenerative Diseases | 编辑 | Abel Lajtha,Naren L. Banik | 视频video | | 图书封面 |  | 描述 | Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of | 出版日期 | Book 2002 | 关键词 | Alzheimer; Nervous System; alzheimer‘s disease; central nervous system; cerebral ischemia; genes; neurodeg | 版次 | 1 | doi | https://doi.org/10.1007/b111075 | isbn_softcover | 978-1-4419-3360-7 | isbn_ebook | 978-0-306-46847-6 | copyright | Springer Science+Business Media New York 2002 |
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