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Titlebook: Role of Melatonin and Pineal Peptides in Neuroimmunomodulation; Franco Fraschini,Russel J. Reiter Book 1991 Springer Science+Business Medi

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书目名称Role of Melatonin and Pineal Peptides in Neuroimmunomodulation
编辑Franco Fraschini,Russel J. Reiter
视频video
丛书名称NATO Science Series A:
图书封面Titlebook: Role of Melatonin and Pineal Peptides in Neuroimmunomodulation;  Franco Fraschini,Russel J. Reiter Book 1991 Springer Science+Business Medi
描述Research related to the pineal gland has advanced rapidly in the last three decades since the discovery of its most important hormone, melatonin. This indoleamine has been shown to have a large variety of effects in the organism; the bulk of these actions were initially thought to relate the pineal gland to the reproductive and endocrine systems. It is now apparent, however, that the physiologic interactions of the pineal and its hormones far transcend its control of endocrine function. One field of pineal research that has developed rapidly within the last 5 years has been the demonstration of its relationship to the immune system. Since the pineal gland is part of the central nervous system, these observations generally fall in the category of neuroimmunology, an area that, in its own right, has received a great deal of attention in the last decade. Thus, a NATO Advanced Study Course entitled "Role of Melatonin and Pineal Pep tides in Neuroimmunomodulation" was convened in Erice, Sicily, on June 3-9, 1990. This book is a result of the scientific presentations given at the workshop. The contributions to the book include mini-review articles which summarized the presentations of th
出版日期Book 1991
关键词attention; central nervous system; immune system; immunology; nervous system
版次1
doihttps://doi.org/10.1007/978-1-4615-3756-4
isbn_softcover978-1-4613-6673-7
isbn_ebook978-1-4615-3756-4
copyrightSpringer Science+Business Media New York 1991
The information of publication is updating

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Interferon-, Modulates Indoleamine Metabolism in Rat Pineal Gland in Organ Culturehat IFN-ɤ exerts dual effects on pineal indoleamine metabolism in rats: one is the suppression of NAT activity, which requires intact pineal sympathetic innervation; and the other is the enhancement of melatonin production, probably, by a suppression of oxidative deamination of 5HT.
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Comparative Studies of VIP-, PHI-, and NPY- Immunoreactive Nerve Fibers in the Pineal Gland of the Sa of the organ (Bowers et al., 1984). Additional to the classical orthosympathetic innervation, a number of anatomical reports indicates the existence of other pathways of innervation of the pineal gland (Korf and Møller, 1984,1985; Møller et al., 1987b).
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New Aspects Concerning the Regulation of Pineal Indoleamine Metabolism: Implications for Neuroimmunohm. The following brief report will describe the generation of the melatonin rhythm, present some examples of factors that change the quantity of pineal melatonin synthesized and released over a 24 hour period, and discuss these changes in terms of their potential relationship to neuroimmunomodulation and tumor growth.
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High-Affinity Melatonin Receptors in Mammals: Localization, G-Protein Coupling and Signal Transductit al., 1989; Carlson et al., 1989; Weaver et al., 1989; Morgan et al., 1989c). The pharmacologic specificity of the high-affinity sites identified in these various tissues is generally in good agreement.
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