Titlebook: Risk Management in Blood Transfusion: The Virtue of Reality; Proceedings of the T C. Th. Smit Sibinga,H. J. Alter Conference proceedings 19

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Risk of Transfusion-Transmitted Infection: A Comparative Analysis of Then and Nowdonor screening assays for HIV and HCV, the advent of solvent detergent and other technologies for the sterilisation of plasma, intensified and more uniform donor questionnaires, increased FDA oversight and the demanding dictates of “Good Manufacturing Practices and most recently, the introduction o

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Transfusion Safety Decisions in the 1990s: Reactions to the Past these events has been undertaken by governmental bodies in developed countries throughout the world [1,2]. These analyses have applied the current state of knowledge about the magnitude and severity of transfusion-transmitted AIDS and non-A non-B hepatitis to decisions made in the 1980s. This has r

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GAT Testing: Added Value?sequence is hybridised by virus specific probes. Various amplification processes of the target (PCR, NASBA, TMA, SDA) or of the probe signal (bDNA, LCR), as well as several detection methods allow for a very high sensitivity. The more general term “nucleic acid amplification testing” (NAT) tends to

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The Role of T and B Cells in Transfusion Related Immune Reac-Tions: Cytokines and the Removal of Apolated and can be influenced by bacterial products, specific immune recognition, other cytokines, Fc-receptor triggering and a variety of biological response modifiers such as prostaglandins. Recently we observed that also coagulation is a major player in this field. Coagulation of whole blood induce

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Involvement of B-Cells in Peripheral Scrapie Pathogenesisile the prototype of all prion diseases, scrapie in sheep and goats, has been known for more than two centuries, a new form of animal prion disease designated bovine spongiform encephalopathy (BSE) has since its first recognition in 1986 developed into an epizootic [7,8]. The emergence of a new vari

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