| 书目名称 | Riboswitches | | 副标题 | Methods and Protocol | | 编辑 | Alexander Serganov | | 视频video | | | 概述 | A comprehensive and timely reference volume for basic and applied research on regulatory RNAs.Covers a wide range of assay formats and systems from the computerized prediction of regulatory RNA elemen | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | The transfer of hereditary information from genes to proteins is one of the essential pr- esses in all living organisms on our planet. Some genes are expressed without modu- tion throughout the life of a cell, while many others require various degrees of control to precisely balance cellular metabolism with environmental conditions. For many years, researchers attributed this regulatory function to protein molecules, which can direct gene expression at multiple levels, in response to various input signals, and with different degrees of selectivity. Even when the control of gene expression was achieved via direct interactions between proteins and mRNAs, the active role was routinely assigned to p- teins, while RNAs were considered merely as recipient molecules. The discovery of RNA interference and multiple bacterial regulatory RNAs caused a shift from the perception of proteins as the predominant regulators of gene expression to the acknowledgement of the importance of RNAs in many regulatory circuits. Such a viewpoint received strong support several years ago after the discovery of riboswitches and related RNA sensors – mRNA regions capable of alternating their conformations in re | | 出版日期 | Book 2009 | | 关键词 | Ligation; Termination; Translation; enzymes; evolution; gene expression; genes; molecular biology; tRNA | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-558-9 | | isbn_softcover | 978-1-61737-947-5 | | isbn_ebook | 978-1-59745-558-9Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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发表于 2025-3-21 16:17:40
