Titlebook: Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Ti; Panos Macheras,Athanasios A. Tsekour

大猩猩

发怨言

Contains access to software that assists in performing modelThis book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of .Finite .Absorption Time .(FAT). In addition, the authors explore the correlated need for re-definition of bio

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Homocystinuria

From Bateman (1910) to Dost (1953)ee radioactive species, namely, mother, daughter, and granddaughter. This equation was adopted by Dost in 1953 to describe the concentration–time curve of drug absorption after oral administration assuming one-compartment model system.

FUSC

The Unphysical Hypothesis of Infinite Absorption Timee constant. It also includes the use of a time-dependent coefficient based on fractal kinetics principles as a more realistic way of describing drug gastrointestinal absorption. The last portion of the chapter focuses on the unphysical assumption associated with the use of Bateman equation in pharma

Extort

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Bioequivalence Under the Prism of Finite Absorption Timetric for the extent of drug absorption. This concept was successfully applied to two published bioavailability digoxin studies. The cumulative ratio of areas as a function of sampling time is suggested as a diagnostic test and criterion for the assessment of the drug’s extent of absorption.

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g in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.978-3-031-20027-4978-3-031-20025-0