Titlebook: Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Ti; Panos Macheras,Athanasios A. Tsekour

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Bioavailability Under the Prism of Finite Absorption Timebed in terms of FAT. Explicit relationships are derived for the bioavailable fraction as a function of the model parameters assuming one-compartment model disposition with zero- or first-order absorption lasting for a certain period of time. An application using a theophylline example is presented. Extent and rate metrics are reinterpreted.

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Bioequivalence Under the Prism of Finite Absorption Timetric for the extent of drug absorption. This concept was successfully applied to two published bioavailability digoxin studies. The cumulative ratio of areas as a function of sampling time is suggested as a diagnostic test and criterion for the assessment of the drug’s extent of absorption.

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978-3-031-20027-4The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

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Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Ti

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Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Ti978-3-031-20025-0