Titlebook: Retroviral Insertion and Oncogene Activation; Hsing-Jien Kung,Peter K. Vogt Book 1991 The Editor(s) (if applicable) and The Author(s), und

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Retroviral Insertion and Oncogene Activation978-3-642-76524-7Series ISSN 0070-217X Series E-ISSN 2196-9965

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0070-217X ontrol over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses a

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Mutagenesis of the Mouse Germline Using Retroviruses,ertional mutagens. The presence of a transposable element within or near the mutant gene acts as a molecular tag which aids in cloning the mutated gene of interest. This approach has been used with great success in several organisms, most notably . (R. 1988).

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Mutagenesis of the Mouse Germline Using Retroviruses,utations in radiation-or chemical-treated mice (GREEN 1981). Although much has been learned from the study of these mutations, molecular analysis of the mutated genes has often been hampered by the lack of molecular access to them. To circumvent this problem, transposable elements can be used as ins

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Insertional Mutagenesis in Mouse Mammary Tumorigenesis, genes provide a particularly good example of the theme of this volume: host cell oncogenes activated by insertion of proviral DNA. They belong especially to this group because most of them have been discovered by virtue of insertional activation, through the application of provirus tagging methods.

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Feline Leukaemia Virus: Generation of Pathogenic and Oncogenic Variants,us-host interaction and generally occurs after a long latent period (H. et al. 1976; J. 1984). For these reasons, it has been customary to classify FeLV as a chronic leukaemogenic retrovirus and to place the acute transforming C-type retroviruses in a separate subclass. In our view, this classificat

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Virus-Host Interactions and the Pathogenesis of Murine and Human Oncogenic Retroviruses, the retroviruses interact with the host in a variety of ways. Thus, viral gene products interact with cellular proteins and modulate or subvert their function. Furthermore, the proviral DNA integrates into the cellular genome introducing mutations which alter the biology of the infected cell. These