书目名称 | Retrotransposition, Diversity and the Brain | 编辑 | Fred H. Gage,Yves Christen | 视频video | | 概述 | Includes supplementary material: | 丛书名称 | Research and Perspectives in Neurosciences | 图书封面 |  | 描述 | The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learne | 出版日期 | Conference proceedings 2008 | 关键词 | DNA; DNA repair; Telomere; endogenous retroviruses; genes; microcephalies; neuropsychiatric disorders; retr | 版次 | 1 | doi | https://doi.org/10.1007/978-3-540-74966-0 | isbn_softcover | 978-3-642-09437-8 | isbn_ebook | 978-3-540-74966-0Series ISSN 0945-6082 Series E-ISSN 2196-3096 | issn_series | 0945-6082 | copyright | Springer-Verlag Berlin Heidelberg 2008 |
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