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Titlebook: Retrotransposition, Diversity and the Brain; Fred H. Gage,Yves Christen Conference proceedings 2008 Springer-Verlag Berlin Heidelberg 2008

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发表于 2025-3-21 16:04:49 | 显示全部楼层 |阅读模式
书目名称Retrotransposition, Diversity and the Brain
编辑Fred H. Gage,Yves Christen
视频video
概述Includes supplementary material:
丛书名称Research and Perspectives in Neurosciences
图书封面Titlebook: Retrotransposition, Diversity and the Brain;  Fred H. Gage,Yves Christen Conference proceedings 2008 Springer-Verlag Berlin Heidelberg 2008
描述The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learne
出版日期Conference proceedings 2008
关键词DNA; DNA repair; Telomere; endogenous retroviruses; genes; microcephalies; neuropsychiatric disorders; retr
版次1
doihttps://doi.org/10.1007/978-3-540-74966-0
isbn_softcover978-3-642-09437-8
isbn_ebook978-3-540-74966-0Series ISSN 0945-6082 Series E-ISSN 2196-3096
issn_series 0945-6082
copyrightSpringer-Verlag Berlin Heidelberg 2008
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0945-6082 iversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learne978-3-642-09437-8978-3-540-74966-0Series ISSN 0945-6082 Series E-ISSN 2196-3096
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Molecular and Circuit Mechanisms for Hippocampal Learning, thesemnemonic requirements. These are the feedforward pathway from the entorhinal cortex (EC) to the dentate gyrus (DG) and on to CA3 for pattern separation, and the recurrent and highly plastic connections in CA3 for pattern completion (Marr 1971;McClelland and Goddard 1996; McNaughton and Nadel 1
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,From the “RNAWorld” to Brain Complexity: Generation of Diversity,lity may contribute to the uniqueness of an individual brain. However, the extent of the impact of L1 on the neuronal genome is unknown. In this chapter we will discuss the potential influence of L1 retrotransposition during brain development and the evolutionary pressures that may have selected thi
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Is Psychosis Due to Retroviral/Retrotransposon Integration Close to the Cerebral Dominance Gene?,has been subject to accelerated evolution with 16 amino acid changing substitutions in PCDHY and, significantly, five changes in PCDHX. Here we investigate the modified viral theory that psychosis is due to a retroviral insertion close to the cerebral dominance gene by examining retroviral sequences
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e, and decision making are more real and, if so, more important than the formal configurations of territorial boundaries. In this conception of political-economy, any group or agent whose actions or ideas shape what is produced/exchanged, by whom, where, and for what rewards and fulfillment, is hist
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Jue Lin,Elissa S. Epel,Elizabeth H. Blackburne, and decision making are more real and, if so, more important than the formal configurations of territorial boundaries. In this conception of political-economy, any group or agent whose actions or ideas shape what is produced/exchanged, by whom, where, and for what rewards and fulfillment, is hist
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