Titlebook: Retinoids; The Biochemical and Heinz Nau,William S. Blaner Book 1999 Springer-Verlag Berlin Heidelberg 1999 Nuclear receptors.Regulation.R

模仿

RAR-Selective Ligands: Receptor Subtype and Function Selectivitydecrease the toxic side effects associated with retinoid therapy. Retinoids are known to mediate many different biological processes, including cellular differentiation and proliferation, epithelial homeostasis, immunocompetence, and embryogenesis (. et al. 1994; .-. 1992). Currently, retinoids are

礼节

Peak-Bone-Mass

GEST

幻想

The Retinoids: Cancer Therapy and Prevention Mechanismsceptor superfamily. Ligand-retinoid receptor interactions lead to activation or repression of target genes which in turn signal retinoid biological actions. There is a convergence of basic scientific and clinical findings in the retinoid field. As a fuller understanding of the retinoid signaling pat

osteopath

Aberrant Expression and Function of Retinoid Receptors in Cancern, reproduction, metabolism, differentiation, bone development, and pattern formation during embryogenesis (. 1991; . et al. 1994; . 1995a). Certain retinoids are capable of modulating cell growth, differentiation, and apoptosis and suppressing carcinogenesis in a variety of tissue types (e.g., lung

LEER

LATER

The Role of Retinoids in Vertebrate Limb Morphogenesis: Integration of Retinoid- and Cytokine-Mediatng been recognized that in the absence of vitamin A, the growth of animals is adversely affected (. and . 1913; . and . 1913). In the 1940s and 1950s, . and colleagues studied the development of vitamin A deficient rats (e.g., W. et al. 1953). These investigations resulted in the identification of a

COMA

Retinoids in Neural Developmentnd doubt, and this chapter presents the data to support this contention. The evidence comes from several types of experiment: the induction of neural differentiation in embryonal carcinoma cells; the effects of excess retinoids; the effects of a deficiency of retinoids; the distribution of retinoid-

Prostatism

Avian Embryo as Model for Retinoid Function in Early Developmentcently become quite clear that the requirement for vitamin A begins with embryonic life, and that retinoids, the vitamin A active forms that exert vitamin A function via their nuclear receptor, are critical signaling molecules during development, their absolute essentialness being best illustrated i