Titlebook: Retinal Degenerative Diseases; Laboratory and Thera Robert E. Anderson,Joe G. Hollyfield,Matthew M. La Book 2010 The Editor(s) (if applicab

范围广

ZBED4, A Novel Retinal Protein Expressed in Cones and Müller Cellsnd . (cone degeneration) dogs. One of the isolated genes encoded ZBED4, a novel protein that in human retina is localized to cone photoreceptors and glial Müller cells. ZBED4 is distributed between nuclear and cytoplasmic fractions of the retina and it readily forms homodimers, probably as a consequ

debacle

Tubby-Like Protein 1 (Tulp1) Is Required for Normal Photoreceptor Synaptic Developmentor degeneration in mice. In wild type (wt) mice, Tulp1 is localized to the photoreceptor inner segment, connecting cilium and synapse. To investigate the role of Tulp1 in the synapse, we examined the pre- and postsynaptic architecture in . mice. We used immunohistochemistry to examine . mice prior t

确定的事

Growth-Associated Protein43 (GAP43) Is a Biochemical Marker for the Whole Period of Fish Optic Nervegeneration process in goldfish is very long and it takes about a half year to fully recover visual function via synaptic refinement. Therefore, we investigated time course of growth-associated protein 43 (GAP43) expression in the goldfish retina for over 6 months after axotomy. In the control retina

Cerumen

Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in alternative splicing and encodes for distinct protein isoforms in the retina. Extensive studies using isoform-specific antibodies and mouse mutants have revealed that RPGR predominantly localizes to the transition zone to primary cilia and associates with selected ciliary and microtubule-associated

Colonoscopy

Carcinogenesis

高射炮

勤劳

The Interphotoreceptor Retinoid Binding (IRBP) Is Essential for Normal Retinoid Processing in Cone Ps the visual response. For photoreceptors to function normally, all-. retinal must be converted back into 11-. retinal through the visual cycle. While rods are primarily responsible for dim light vision, the ability of cones to function in constant light is essential to human vision and may be facil

Servile

Aseptic Injury to Epithelial Cells Alters Cell Surface Complement Regulation in a Tissue Specific Fand permits increased activation of complement when the cells are subsequently exposed to serum. Based upon these results, we hypothesized that RPE cells respond to cellular stress as if it is infection, and reduce their surface expression of complement regulatory proteins to foster the local immune

interference

Analysis of Genes Differentially Expressed During Retinal Degeneration in Three Mouse Modelsare characterized by rhodopsin abnormalities, death is due to the TNF pathway. In addition, there are a number of unknown genes not yet annotated in each of the models that could be promising in revealing novel functions in photoreceptors.