Titlebook: Retinal Degenerative Diseases; Laboratory and Thera Robert E. Anderson,Joe G. Hollyfield,Matthew M. La Book 2010 The Editor(s) (if applicab

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Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated ining. We also provide new evidence that suggests the existence of discrete RPGR multiprotein complexes in photoreceptors. Piecing together the RPGR-interactome in different subcellular compartments should provide critical insights into the role of alternative RPGR isoforms in associated orphan and syndromic retinal degenerative diseases.

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Analysis of Genes Differentially Expressed During Retinal Degeneration in Three Mouse Modelsthe intention of identifying common cell death pathways that result in RP, the pattern of global gene expression in three different mouse models of retinal degeneration was analyzed using DNA arrays. The models used were .., a transgenic mouse line that expresses a mutant form of opsin with a deleti

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Protein Kinase C Regulates Rod Photoreceptor Differentiation Through Modulation of STAT3 Signalingctivation of STAT3 by cytokines such as LIF and CNTF specifically blocks differentiation of rod photoreceptors. Here we test the hypothesis that PKC activation promotes development of rod photoreceptors by inhibiting STAT3. Explant cultures of mouse retina were used to study the effects of PKC activ

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The Function of Oligomerization-Incompetent RDS in Rodsares features in common with other tetraspanin proteins, including the existence of a large intradiscal D2 loop containing several cysteines. While these cysteines are used only for intramolecular disulfide bonds in most tetraspanins, RDS expresses a seventh, unpaired cysteine (C150) used for interm

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