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Titlebook: Retinal Degenerative Diseases; Mechanisms and Exper John D. Ash,Robert E. Anderson,Christian Grimm Conference proceedings 2018 Springer Int

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书目名称Retinal Degenerative Diseases
副标题Mechanisms and Exper
编辑John D. Ash,Robert E. Anderson,Christian Grimm
视频video
概述Presents several new aspects of gene therapy and revolutionary new imaging and functional testing.Explores the role of inflammation and immunity, as well as other basic mechanisms in age-related macul
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Retinal Degenerative Diseases; Mechanisms and Exper John D. Ash,Robert E. Anderson,Christian Grimm Conference proceedings 2018 Springer Int
描述.The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.. . While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the r
出版日期Conference proceedings 2018
关键词animal models; oxidative stress; carotenoids; photoreceptor; macular degeneration; inflammation; gene ther
版次1
doihttps://doi.org/10.1007/978-3-319-75402-4
isbn_softcover978-3-030-09221-4
isbn_ebook978-3-319-75402-4Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer International Publishing AG, part of Springer Nature 2018
The information of publication is updating

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Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/r/image/829208.jpg
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MicroRNA as Therapeutics for Age-Related Macular DegenerationXu .), relatively little research has been conducted into the therapeutic potential of miRNAs for the treatment of AMD. This review will investigate the use of miRNAs as therapeutic and diagnostic molecules for AMD.
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Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epitheliumivered subretinally to mouse RPE cells, the mutant impairs the wild-type protein secretion from the RPE, and both proteins are dispersed toward the basal and lateral RPE membrane. This result has mechanistic and therapeutic implications for L-ORD disorder.
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Antisense Oligonucleotide-Based Splice Correction of a Deep-Intronic Mutation in , Underlying Choroi intronic mutation in . underlying Leber congenital amaurosis. Here, we expand the use of these therapeutic molecules for the c.315-4587T>A deep-intronic mutation in . by demonstrating splice correction in patient-derived lymphoblast cells.
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