Titlebook: Resistance to Proteasome Inhibitors in Cancer; Molecular Mechanisms Q. Ping Dou Book 2014 Springer International Publishing Switzerland 201

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Oxidative Stress and the Proteasome: Mechanisms and Therapeutic Relevance,ses, and the proteasome can mediate ROS levels by degrading proteins that generate ROS and by controlling antioxidant turnover, as well as by clearing oxidatively damaged proteins from cells. The proteasome itself is also regulated by ROS, with certain subunits being susceptible to oxidative modific

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The 26S Proteasomal ATPases: Structure, Function, Regulation, and Potential for Cancer Therapies,of cellular processes (e.g., cell proliferation, differentiation, transcription, and signal transduction), and it is essential for cell survival. The multistep process of protein degradation by the 26S proteasome begins with the recognition of substrates by the 19S regulatory particle and ends with

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Book 2014el combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechan

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Proteotoxic Stress and Proteasome Inhibitor Efficacy and Resistance,re I will discuss our current understanding of the role of proteotoxicity in the antitumor activities of proteasome inhibitors and the evidence that induced cytoprotective mechanisms could play important roles in mediating resistance.