书目名称 | Resistance to Proteasome Inhibitors in Cancer | 副标题 | Molecular Mechanisms | 编辑 | Q. Ping Dou | 视频video | | 概述 | Reveals latest discoveries related to the molecular mechanisms of proteasome inhibitor resistance.Discusses proteasome inhibitor resistance in multiple contexts, including multiple myeloma, leukemia, | 丛书名称 | Resistance to Targeted Anti-Cancer Therapeutics | 图书封面 |  | 描述 | .The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume..This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.. | 出版日期 | Book 2014 | 关键词 | 20S proteasome inhibitors; bortezomib; carfizomib; leukemia; multiple myeloma; ubiquitin-proteasome pathw | 版次 | 1 | doi | https://doi.org/10.1007/978-3-319-06752-0 | isbn_softcover | 978-3-319-37703-2 | isbn_ebook | 978-3-319-06752-0Series ISSN 2196-5501 Series E-ISSN 2196-551X | issn_series | 2196-5501 | copyright | Springer International Publishing Switzerland 2014 |
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