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Titlebook: Resistance to Proteasome Inhibitors in Cancer; Molecular Mechanisms Q. Ping Dou Book 2014 Springer International Publishing Switzerland 201

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发表于 2025-3-21 17:14:32 | 显示全部楼层 |阅读模式
书目名称Resistance to Proteasome Inhibitors in Cancer
副标题Molecular Mechanisms
编辑Q. Ping Dou
视频video
概述Reveals latest discoveries related to the molecular mechanisms of proteasome inhibitor resistance.Discusses proteasome inhibitor resistance in multiple contexts, including multiple myeloma, leukemia,
丛书名称Resistance to Targeted Anti-Cancer Therapeutics
图书封面Titlebook: Resistance to Proteasome Inhibitors in Cancer; Molecular Mechanisms Q. Ping Dou Book 2014 Springer International Publishing Switzerland 201
描述.The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume..This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies..
出版日期Book 2014
关键词20S proteasome inhibitors; bortezomib; carfizomib; leukemia; multiple myeloma; ubiquitin-proteasome pathw
版次1
doihttps://doi.org/10.1007/978-3-319-06752-0
isbn_softcover978-3-319-37703-2
isbn_ebook978-3-319-06752-0Series ISSN 2196-5501 Series E-ISSN 2196-551X
issn_series 2196-5501
copyrightSpringer International Publishing Switzerland 2014
The information of publication is updating

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发表于 2025-3-21 22:55:29 | 显示全部楼层
Preclinical Studies on the Molecular Basis of Bortezomib Resistance and Modalities to Overcome Resiercome resistance, e.g., by novel proteasome inhibitors and combinations of bortezomib with other chemotherapeutic drugs. Finally, an update is provided of the ongoing clinical trials investigating the potential benefits of proteasome inhibitors in acute leukemia.
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Resistance to Proteasome Inhibitors in Multiple Myeloma, bone destruction, anemia, hypercalcemia, and renal failure. Although MM remains incurable, a dramatic paradigm shift in the treatment of MM has occurred over the past decade through the introduction of novel agents, including the development of small molecule inhibitors targeting the proteasome. Am
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Overcoming Inherent Resistance to Proteasome Inhibitors in Head and Neck Cancer: Challenges and Newthe in vitro sensitivity of HNSCC cells to proteasome inhibitors, clinical testing of bortezomib in HNSCC patients has encountered obstacles of inherent resistance and adverse toxicities. To combat these difficulties, current efforts are focused on developing strategies that co-target the proteasome
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